Microsoft Lightswitch
Lightswitch 2011 has been released now and if you haven't already checked it out, you should. We have been testing it through the beta cycle on an internal project and our experience has been extremely positive. Like any new technology there are little quirks to learn and accept but overall it is a great productivity enhancer.
It is also widely supported already by web hosts who are setup and compliant with the Microsoft Web Deploy services (through WebMatrix, Visual Studio, and other supported tools). If you don't want to use Web Deploy to push your Lightswitch project up to your web host, well, then it gets vastly more complicated. I've read articles by people who have gotten it working manually, but it is no small task. It is strongly recommended that you use the Web Deploy services.
Happy Hosting!